来自日本蛇菰的新苯丙素类化合物和体外α-葡萄糖苷酶抑制剂。

New phenylpropanoids and in vitro α-glucosidase inhibitors from Balanophora japonica.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.

出版信息

Planta Med. 2011 Mar;77(5):477-81. doi: 10.1055/s-0030-1250464. Epub 2010 Oct 26.

DOI:10.1055/s-0030-1250464

PMID:20979022

Abstract

Five new phenylpropanoids, named balajaponins A-E (1-5), were isolated from Balanophora japonica, along with 24 known compounds. Among them, three hydrolysable tannins (6-8) showed specific in vitro α-glucosidase inhibition, with IC₅₀ values in the range of 1-4 µM. Kinetic analysis revealed that they all acted in a noncompetitive mode.

摘要

从日本蛇菰中分离得到五个新的苯丙烷类化合物，命名为巴兰素 A-E（1-5），同时还分离得到了 24 个已知化合物。其中，三种可水解鞣质（6-8）表现出对体外α-葡萄糖苷酶的特异性抑制作用，IC₅₀ 值在 1-4 μM 范围内。动力学分析表明它们均以非竞争性模式作用。