来自日本蛇菰的细胞毒性可水解单宁。

Cytotoxic hydrolyzable tannins from Balanophora japonica.

作者信息

Jiang Zhi-Hong, Wen Xiao-Yun, Tanaka Takashi, Wu Shao-Yu, Liu Zhongqiu, Iwata Hiromi, Hirose Yoko, Wu Shuguang, Kouno Isao

机构信息

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China.

出版信息

J Nat Prod. 2008 Apr;71(4):719-23. doi: 10.1021/np070519+. Epub 2008 Feb 27.

DOI:10.1021/np070519+

PMID:18302336

Abstract

Four hydrolyzable tannins named balanophotannins D-G ( 1- 4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D ( 1) and F ( 3) were determined via the PGME method. Balanophotannin E ( 2) showed cytotoxicity to Hep G2 cancer cells with an IC 50 value of 4.22 microM.

摘要

从寄生植物日本蛇菰的地上部分分离出四种可水解单宁，命名为蛇菰单宁D-G（1-4）。根据光谱和化学证据对它们的结构进行了表征。蛇菰单宁D-G含有一个氧化的六羟基二苯甲酰基（HHDP）基团。通过PGME方法确定了蛇菰单宁D（1）和F（3）的绝对构型。蛇菰单宁E（2）对肝癌细胞Hep G2具有细胞毒性，IC50值为4.22微摩尔。