Zhang He-jun, Jin Zhu, Lin San-ren, Ding Shi-gang, Bai Peng, Cui Rong-li, Han Ya-jing, Zhang Ying, Shang Hui-ru
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Zhonghua Nei Ke Za Zhi. 2010 Aug;49(8):688-90.
Collagenous gastritis is a rare entity, characterized by the deposition of a subepithelial collagen band with an inflammatory infiltrate in the mucosa. This report describes the first case of collagenous gastritis occurring in a young Chinese woman and reviews the literatures.
The patient underwent the gastroscopy screening, and the biopsy specimens were treated with HE staining, Masson staining, Congo red staining and Warthin-Starry staining.Patients' clinical data was discussed and followed up.
A twenty-year-old girl had intermittent epigastric pain for 4 years, abdominal distention, hiccup and weight loss for two months. The gastric endoscopy revealed diffuse white nodular appearance of the mucosa in angular incisura and antrum. Pathologic examination of the gastric biopsies from the antrum and angular showed a subepithelial collagen deposition with moderate infiltrates of lymph plasma cells and eosinophils of the lamina propria. The collagen band measured up to 120.3 µm (mean 43.8 µm). Prednisone 20 mg/d for 4 weeks led to clinical remission and weight gain.
There are about 40 cases in literatures to date, and the cause and pathogenesis of collagenous gastritis remain unknown. According to the clinical and pathological characteristics, the patient in this article is the subtype of collagenous gastritis that occurring in children and young adults. Specific therapy has not been established, the gluten-free diet and glucocorticosteroid may be helpful to relieve symptoms in collagenous gastritis patients.
胶原性胃炎是一种罕见疾病，其特征为黏膜下胶原带沉积伴炎症浸润。本报告描述了首例发生在一名年轻中国女性身上的胶原性胃炎病例并对相关文献进行综述。
患者接受胃镜筛查，活检标本进行苏木精-伊红染色、Masson染色、刚果红染色和Warthin-Starry染色。对患者的临床资料进行讨论并随访。
一名20岁女孩间歇性上腹部疼痛4年，腹胀、呃逆2个月，体重减轻。胃镜检查显示胃角切迹和胃窦黏膜呈弥漫性白色结节样外观。胃窦和胃角活检病理检查显示黏膜下胶原沉积，固有层有中等程度的淋巴浆细胞和嗜酸性粒细胞浸润。胶原带厚度达120.3μm（平均43.8μm）。泼尼松20mg/d治疗4周后临床症状缓解，体重增加。
迄今为止文献报道约40例，胶原性胃炎的病因和发病机制尚不清楚。根据临床和病理特征，本文患者为儿童及青年型胶原性胃炎亚型。尚未确立特异性治疗方法，无麸质饮食和糖皮质激素可能有助于缓解胶原性胃炎患者的症状。
