DNA 损伤反应。
DNA damage response.
机构信息
Department of Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
出版信息
Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a000745. doi: 10.1101/cshperspect.a000745.
Abstract
Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.
摘要
DNA 的结构变化会严重影响其功能，如复制和转录，并在与年龄相关的疾病和癌症中发挥重要作用。一个复杂而纠结的 DNA 损伤反应 (DDR) 机制网络，包括多种 DNA 修复途径、损伤容忍过程和细胞周期检查点，可保护基因组的完整性。与转录和复制一样，DDR 是一个与染色质相关的过程，通常在时间和空间上受到严格控制。由于 DNA 损伤可能随时随地发生在任何基因组位置，因此需要对这种防御装置进行专门的时空协调。
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