Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sci Transl Med. 2010 Oct 27;2(55):55ps52. doi: 10.1126/scitranslmed.3001722.
New insights on the role of costimulatory molecules in T helper cell function have yielded exciting alternatives to the development of therapeutic strategies that target T cell costimulatory pathways. Inducible costimulatory molecule (ICOS) signaling is now shown by Paulos and colleagues to support expansion of human T helper 17 (T(H)17) cells that could exert antitumor activity. Here we discuss (i) how these findings aid in our understanding of mechanisms that govern T(H)17 cell functions and (ii) the potential application of these new insights to the development of immunotherapies.
新的见解表明共刺激分子在 T 辅助细胞功能中的作用，为开发靶向 T 细胞共刺激途径的治疗策略提供了令人兴奋的选择。诱导共刺激分子（ICOS）信号现在由 Paulos 及其同事证明支持人类 T 辅助 17（T(H)17）细胞的扩增，这可能发挥抗肿瘤活性。在这里，我们讨论了（i）这些发现如何帮助我们理解控制 T(H)17 细胞功能的机制，以及（ii）这些新见解在开发免疫疗法方面的潜在应用。
