Department of Pharmacology and Toxicology, University of Zurich, Switzerland. steven.brown @ pharma.uzh.ch
Gerontology. 2011;57(5):427-34. doi: 10.1159/000320673. Epub 2010 Oct 28.
From circulation to digestion to excretion, a circadian clock synchronizes most aspects of mammalian physiology with the solar day. During normal ageing, this daily coordination gradually erodes, and during pathological ageing such erosion is exacerbated. Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients. Hence, a better understanding of the interactions between the circadian clock and ageing - at both cellular and systemic levels - could lead to direct benefits for aged individuals.
从循环到消化再到排泄，生物钟使哺乳动物的大多数生理过程与太阳日同步。在正常衰老过程中，这种日常协调逐渐减弱，而在病理性衰老过程中，这种减弱会加剧。最近的实验表明，旨在维持生物钟功能的疗法可以提高老年患者的生活质量。因此，更好地了解生物钟与衰老之间的相互作用——在细胞和系统水平上——可能会给老年人带来直接的好处。
