Center for Gene Regulation in Health and Diseases and BGES Department, Cleveland State University , Ohio , USA.
Ann Med. 2014 Jun;46(4):189-90. doi: 10.3109/07853890.2014.920213.
Chronotherapy of cancer is one of the oldest examples of the clinical application of biological rhythms. Growing understanding of the importance of biological timing in physiology and pathophysiology of many diseases including cancer reforms our views on the role of biological clocks in cancer and cancer treatment. In the present issue the current progress in circadian clock-dependent mechanisms of cancer, polymorphism and mutations of clock gene in cancer, cancer-associated clock disruptions, and novel chronotherapeutic approaches are discussed.
癌症的时间治疗学是生物节律在临床应用上最古老的范例之一。人们对生物时间在许多疾病（包括癌症）的生理学和病理生理学中的重要性的认识不断加深，这改变了我们对生物钟在癌症和癌症治疗中的作用的看法。本期内容讨论了生物钟依赖性机制在癌症中的最新进展、癌症时钟基因的多态性和突变、与癌症相关的时钟紊乱，以及新的时间治疗方法。
