Brooks Audrey J, Bell Iris R, Howerter Amy, Jackson Nicholas, Aickin Mikel
Department of Psychology, the University of Arizona, Tucson, AZ 85721, USA.
Forsch Komplementmed. 2010 Oct;17(5):250-7. doi: 10.1159/000320952. Epub 2010 Oct 1.
BACKGROUND/AIMS: The purpose of this within-subjects feasibility study was to determine whether two different homeopathic remedies, Nux Vomica (NV) and Coffea Cruda (CC), exert effects on subjective mood ratings in healthy adults with a history of coffee-induced insomnia. The impact of individual personality traits, anxiety sensitivity or Type A cynical hostility, and homeopathic constitutional type (HTYPE-NV, HTYPE-CC), on remedy effects was examined to evaluate differential responsivity, in accord with clinical claims.
Young adults of both sexes (ages 18-31) with above-average scores on standardized personality scales for either cynical hostility or anxiety sensitivity, and a history of coffee-induced insomnia, participated in the month-long study. At-home polysomnographic recordings were obtained on successive pairs of nights once per week for a total of 8 recordings (nights 1, 2, 8, 9, 15, 16, 22, 23). Subjects (N = 59) received placebo pellets on night 8 (single-blind) and verum pellets in 30c doses of one of two homeopathic remedies, NV or CC, on night 22 (doubleblind). Subjects completed the Profile of Mood States Scales at bedtime.
The remedies produced differential effects on anger and overall mood, with improved mood following CC administration. A similar trend for depression was observed. Anxiety sensitive subjects experienced less tension following CC, whereas hostile subjects receiving CC became more tense. The high HTYPE-CC receiving CC experienced less vigor. The high HTYPE-CC receiving NV experienced more vigor.
背景/目的：这项自身对照可行性研究的目的是确定两种不同的顺势疗法药物，马钱子（NV）和咖啡（CC），对有咖啡诱发失眠病史的健康成年人的主观情绪评分是否有影响。根据临床主张，研究了个体人格特质、焦虑敏感性或A型愤世嫉俗敌意以及顺势疗法体质类型（HTYPE-NV、HTYPE-CC）对药物效果的影响，以评估差异反应性。
在标准化人格量表上愤世嫉俗敌意或焦虑敏感性得分高于平均水平且有咖啡诱发失眠病史的18至31岁青年男女参与了为期一个月的研究。每周一次，连续两个晚上进行家庭多导睡眠图记录，共8次记录（第1、2、8、9、15、16、22、23晚）。受试者（N = 59）在第8晚接受安慰剂丸剂（单盲），在第22晚接受两种顺势疗法药物之一NV或CC的30c剂量的真品丸剂（双盲）。受试者在睡前完成情绪状态量表。
这些药物对愤怒和总体情绪产生了不同的影响，服用CC后情绪有所改善。观察到抑郁有类似趋势。焦虑敏感的受试者在服用CC后紧张感减轻，而接受CC的敌意受试者变得更加紧张。接受CC的高HTYPE-CC受试者活力降低。接受NV的高HTYPE-CC受试者活力增强。
