Lee K H, Lee J S, Kim S H
Department of Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Korean J Intern Med. 1990 Jul;5(2):112-7. doi: 10.3904/kjim.1990.5.2.112.
Three cases of cardiotoxicity manifested by chest pain, tachycardia, respiratory distress, and electrocardiographic changes simulating acute myocardial infarction or ischemia were observed during the course of combination chemotherapy with etoposide, cisplatin, and continuous infusion of 5-fluorouracil in patients with advanced non-small cell lung cancer. There was no cardiac enzyme elevation. A similar but rare clinical syndrome has been described in association with 5-fluorouracil infusion as a single agent or in combination with other chemotherapeutic agents. We describe the cases and review their possible pathogeneses and clinical implications.
在晚期非小细胞肺癌患者接受依托泊苷、顺铂及持续输注5-氟尿嘧啶联合化疗过程中，观察到3例出现心脏毒性，表现为胸痛、心动过速、呼吸窘迫以及类似急性心肌梗死或缺血的心电图改变。心肌酶无升高。一种类似但罕见的临床综合征已被描述与单独使用5-氟尿嘧啶输注或与其他化疗药物联合使用有关。我们描述这些病例并综述其可能的发病机制及临床意义。
