Petrella V, Alciato P, Cantone P A, Fico D, Gagliardini R
Regione Piemonte, U.S.S.L. n. 49, Ospedale di Varallo Sesia, Divisionedi Medicina Generale.
Minerva Med. 1989 Mar;80(3):305-7.
The cardiotoxicity of cytostatic drugs reported in the literature is marked for some (adriamycin), rather rare for others. Cases of angina, infarction, and atrial arrhythmia have been reported during treatment with cisplatin. The case is reported of a 65-year-old patient with no risk factors for cardiovascular disease who had two attacks of high-frequency atrial arrhythmia during combined treatment with cisplatin and etoposide. The first attack came after the first cycle and disappeared spontaneously; the second, after the second cycle, required antiarrhythmic treatment. The potential myocardial toxicity of cisplatin, especially when combined with other potentially cardiotoxic drugs or administered after cycles of adriamycin is discussed.
文献报道的细胞毒性药物的心脏毒性，对某些药物（如阿霉素）而言很显著，对其他药物则较为罕见。在用顺铂治疗期间，已有心绞痛、心肌梗死和房性心律失常的病例报道。本文报告了一例65岁无心血管疾病危险因素的患者，在顺铂和依托泊苷联合治疗期间发生了两次高频房性心律失常发作。第一次发作在第一个疗程后出现，随后自行消失；第二次发作在第二个疗程后出现，需要抗心律失常治疗。文中讨论了顺铂潜在的心肌毒性，尤其是与其他潜在心脏毒性药物联合使用时，或在阿霉素疗程后使用时。
