Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
Med Sci Monit. 2010 Nov;16(11):CR536-9.
Obesity is associated with an increased risk of developing insulin resistance, hyperinsulinemia, glucose intolerance, dyslipidemia, hypertension, premature atherosclerosis, and coronary artery disease. This study is designed to compare serum asymmetric dimethylarginine (ADMA) levels between obese individuals and controls.
MATERIAL/METHODS: Fifty volunteers, 30 obese (13 men; mean age, 40±11 years) and 20 healthy controls (13 men; mean age, 44±10 years) were enrolled to this study. Measurement of ADMA was accomplished by high performance liquid chromatography.
The mean body mass index of the obese group was significantly higher than that of the control group (35±4 vs 26±3 kg/m2; P=.001). The mean waist circumference of the obese subjects was also significantly higher compared with controls (111±11 vs 93±10 cm; P=.001). No significant difference was found concerning age, sex, blood pressures, and biochemistry parameters. Serum ADMA levels were significantly higher in obese individuals compared with healthy controls (5.4±3.3 vs 3.1±1.8 µmol/L; P=.006). A weak but significant correlation was identified between serum ADMA concentration and the waist circumference (r=0.282, P=.047).
The results of the present study demonstrated that serum ADMA levels of normotensive obese individuals were significantly higher than healthy controls. Increased ADMA concentrations observed only in the obese group were deemed to be important regarding the development future of cardiovascular disease in the future.
肥胖与胰岛素抵抗、高胰岛素血症、葡萄糖耐量异常、血脂异常、高血压、动脉粥样硬化过早发生和冠心病的风险增加有关。本研究旨在比较肥胖个体和对照组之间的血清不对称二甲基精氨酸（ADMA）水平。
材料/方法：本研究纳入了 50 名志愿者，其中 30 名肥胖者（13 名男性；平均年龄 40±11 岁）和 20 名健康对照组（13 名男性；平均年龄 44±10 岁）。通过高效液相色谱法测量 ADMA。
肥胖组的平均体重指数明显高于对照组（35±4 比 26±3 kg/m2；P=.001）。肥胖组的平均腰围也明显大于对照组（111±11 比 93±10 cm；P=.001）。年龄、性别、血压和生化参数无显著差异。肥胖个体的血清 ADMA 水平明显高于健康对照组（5.4±3.3 比 3.1±1.8 µmol/L；P=.006）。血清 ADMA 浓度与腰围之间存在弱但有统计学意义的相关性（r=0.282，P=.047）。
本研究结果表明，血压正常的肥胖个体的血清 ADMA 水平明显高于健康对照组。仅在肥胖组中观察到的 ADMA 浓度增加被认为与未来心血管疾病的发生有关。
