Gruber H-J, Mayer C, Meinitzer A, Almer G, Horejsi R, Möller R, Pilz S, März W, Gasser R, Truschnig-Wilders M, Mangge H
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Exp Clin Endocrinol Diabetes. 2008 Oct;116(9):520-4. doi: 10.1055/s-2008-1062712. Epub 2008 Apr 1.
Asymmetrical dimethylarginine (ADMA) was found to be increased in conditions associated with atherosclerosis and metabolic disorders. We investigated ADMA in obese juveniles with pre-atherosclerotic symptoms and in normal weight juveniles.
To elucidate correlations of ADMA in juveniles with obesity related disorders such as insulin resistance, low grade inflammation, hypertension and pre-atherosclerosis, we analysed ADMA by high performance liquid chromatography (HPLC) in 68 obese and 68 healthy, age and gender matched juveniles.
ADMA levels are slightly, but significantly increased (p=0.04) in obese (0.78+/-0.01 micromol/l), compared to normal weight juveniles (0.74+/-0.01 micromol/l). There are no robust correlations of ADMA with obesity related disorders, like dyslipidemia, hypertension, low-grade inflammation and pre-atherosclerosis. Age, body length and alkaline phosphatase, as markers of growth are correlated with ADMA. Multiple testing revealed that, alkaline phosphatase turned out as highly significant positively correlated with ADMA in normal weight (r=0.45/p<0.0001) and obese (r=0.59/p<0.0001) children.
We show here, that ADMA is slightly increased in obese juveniles without any robust correlations to obesity related disorders. ADMA is tightly correlated with alkaline phosphatase as a marker of growth in obese and normal weight, healthy juveniles.
非对称二甲基精氨酸（ADMA）在与动脉粥样硬化和代谢紊乱相关的病症中含量会升高。我们对有动脉粥样硬化前期症状的肥胖青少年和正常体重青少年的ADMA进行了研究。
为了阐明青少年体内ADMA与肥胖相关疾病（如胰岛素抵抗、低度炎症、高血压和动脉粥样硬化前期）之间的相关性，我们采用高效液相色谱法（HPLC）对68名肥胖青少年和68名年龄及性别匹配的健康青少年的ADMA进行了分析。
与正常体重青少年（0.74±0.01微摩尔/升）相比，肥胖青少年（0.78±0.01微摩尔/升）的ADMA水平略有升高，但差异具有统计学意义（p = 0.04）。ADMA与肥胖相关疾病（如血脂异常、高血压、低度炎症和动脉粥样硬化前期）之间没有显著相关性。年龄、身长和作为生长标志物的碱性磷酸酶与ADMA相关。多重检验显示，在正常体重儿童（r = 0.45/p < 0.0001）和肥胖儿童（r = 0.59/p < 0.0001）中，碱性磷酸酶与ADMA呈高度显著正相关。
我们在此表明，肥胖青少年的ADMA略有升高，但与肥胖相关疾病没有显著相关性。在肥胖和正常体重的健康青少年中，ADMA与作为生长标志物的碱性磷酸酶密切相关。
