Department of Cardiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey.
Med Sci Monit. 2010 Nov;16(11):CR545-8.
The aim of this study was to investigate whether the amount of urinary albumin concentration (UAC) or urinary albumin to creatinine ratio (UACR) is more strongly associated with angiographically documented coronary artery disease (CAD).
MATERIAL/METHODS: A total of 199 consecutive patients [11 9(60%) male, 80 (40%) female, mean age =57±10] undergoing diagnostic coronary angiography were included in the study. Significant coronary artery disease was defined as a stenosis equal to or above 50% in the main coronary artery or in one of the other branches. UAC and UACR were calculated from the urine. Baseline clinical parameters, UAC and UACR were compared between subjects with and without CAD. Factors predicting CAD were evaluated by multivariate analysis.
Baseline clinical and laboratory characteristics of patients with and without CAD were not different except for a slightly male predominance in patients with CAD. Patients with CAD had significantly higher UACs and UACRs than patients without CAD (32.14±31.27 mg/day vs. 15.61±16.70 mg/day, p=0.01; 9.11±7.42 mg/g vs. 4.80±3.28 mg/g, p=0.009). A positive correlation was found between Gensini score and UACR (p=0.01), whereas no correlation was found between Gensini and UAC. UACR was the only significant parameter for the presence of CAD in the multivariate analysis adjusted for age, sex, other well known CAD risk factors, UAC and UACR.
Our preliminary results suggest that UACR is more closely associated with angiography documented CAD than is the level of UAC itself, but UACR maybe more significantly associated with angiography documented CAD than with the levels of UAC.
本研究旨在探讨尿白蛋白浓度（UAC）或尿白蛋白与肌酐比值（UACR）与血管造影证实的冠心病（CAD）的相关性是否更强。
材料/方法：本研究共纳入 199 例连续患者（119 例男性[60%]，80 例女性[40%]，平均年龄=57±10 岁），均接受诊断性冠状动脉造影。将主冠状动脉或其他分支狭窄≥50%定义为有意义的冠状动脉疾病。UAC 和 UACR 来自尿液计算。比较 CAD 患者和无 CAD 患者的基线临床参数、UAC 和 UACR。采用多元分析评估 CAD 的预测因素。
除 CAD 患者中男性略多外，CAD 患者和无 CAD 患者的基线临床和实验室特征无差异。CAD 患者的 UAC 和 UACR 显著高于无 CAD 患者（32.14±31.27mg/天 vs. 15.61±16.70mg/天，p=0.01；9.11±7.42mg/g vs. 4.80±3.28mg/g，p=0.009）。Gensini 评分与 UACR 呈正相关（p=0.01），而 Gensini 评分与 UAC 无相关性。在校正年龄、性别、其他已知 CAD 危险因素、UAC 和 UACR 后，多元分析中 UACR 是 CAD 存在的唯一显著参数。
我们的初步结果表明，UACR 与血管造影证实的 CAD 的相关性比 UAC 本身更密切，但 UACR 与血管造影证实的 CAD 的相关性可能比 UAC 更显著。
