Marden L J, Reddi A H, Hollinger J O
Walter Reed Army Medical Center, Washington, DC.
J Craniofac Surg. 1990 Jul;1(3):154-60.
Repair of craniofacial bone often requires autogenous or allogeneic bone. Natural materials deliver bone-inducing substances to wound beds and provide scaffolding for osteoconduction, but not without risk of morbidity. We are developing a synthetic material consisting of proteins which stimulate bone repair encased within a moldable, biodegradable delivery system. The stages of bone induction include chemoattraction of stem cells, proliferation and differentiation of these cells to competent chondrocytes and osteoblasts, angiogenesis, mineralization, and remodeling. Bovine osteogenin induces bone formation in soft tissue in rats, and accelerates bone repair in cranial defects. The protein has been purified and partially sequenced. Growth factors may augment the inductive effects of osteogenin by attracting preosteoblasts, accelerating their proliferation, and stimulating angiogenesis. A composite material of osteogenin and growth factors released from a biodegradable delivery system in a time-dependent fashion is proposed to decrease the necessity for autogenous and allogeneic bone implants.
颅面骨修复通常需要自体骨或异体骨。天然材料可将骨诱导物质输送至伤口床，并为骨传导提供支架，但并非没有发病风险。我们正在研发一种合成材料，它由包裹在可塑形、可生物降解递送系统内的能刺激骨修复的蛋白质组成。骨诱导的阶段包括干细胞的化学吸引、这些细胞增殖并分化为有功能的软骨细胞和成骨细胞、血管生成、矿化和重塑。牛骨生成蛋白可诱导大鼠软组织内骨形成，并加速颅骨缺损的骨修复。该蛋白质已被纯化并部分测序。生长因子可通过吸引前成骨细胞、加速其增殖并刺激血管生成来增强骨生成蛋白的诱导作用。有人提出，一种由骨生成蛋白和生长因子组成的复合材料，以时间依赖性方式从可生物降解递送系统中释放，可减少自体骨和异体骨植入的必要性。
