Schweiberer L, Hallfeldt K, Mandelkow H
Orthopade. 1986 Feb;15(1):3-9.
Osteoinduction is a biological principle. The implantation of tissue with inductive properties results in the proliferation and differentiation of undifferentiated cells to cartilage and bone. This process, which is similar to a cascade-type mechanism, is controlled by a series of humoral and local growth factors. It was possible to isolate a number of macromolecular substances with osteoinductive, mitogenic, or chemotactic properties specifically from the extracellular bone matrix. A deeper understanding of the regulative mechanisms as well as the greater availability of growth factors may lead to new therapeutic approaches in bone surgery.
骨诱导是一种生物学原理。植入具有诱导特性的组织会导致未分化细胞增殖并分化为软骨和骨。这个过程类似于级联式机制，由一系列体液和局部生长因子控制。从细胞外骨基质中特异性分离出许多具有骨诱导、促有丝分裂或趋化特性的大分子物质成为可能。对调节机制的更深入理解以及生长因子更易获取，可能会带来骨外科手术的新治疗方法。
