[In vitro evaluation of antibacterial activity of the original oxime type of beta-lactam antibiotics with the 4-aminobenzensulfonamide group].

Four newly prepared beta-lactam antibiotics of the oxime type with a 4-aminobenzensulphonamidogroup, synthetized at the Research Institute for Pharmacy and Biochemistry, Prague, were subjected to an evaluation of antibacterial efficacy in vitro. The evaluation was carried out by determining the minimal inhibitory concentration (MIC) in 47 clinical strains and 6 standard strains (Staphylococcus aureus, Streptococcus pyogenes and facecalis, E. coli, Enterobacter and Proteus spec., Pseudomonas aeruginosa). The results were compared with the MIC of cefalexin, cefoxitin, cefazolin, cefsulodin, and ampicillin. The antibacterial effect of these agents was lower than that of the compared antibiotics. It was slightly better in the pseudomonadic strains, where the efficacy of cefusulodin was best and the other four antibiotics appeared to be worst.