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[伴有甲状腺功能亢进、肢端肥大症和低磷血症-高磷尿性佝偻病的McCune-Albright综合征]

[The McCune-Albright syndrome with hyperthyroidism, acromegaly and hypophosphatemic-hyperphosphaturic rickets].

作者信息

Vuković D, Katanić D, Panić V, Vlaski J

机构信息

Institut za zdravstvenu zastitu majke i deteta, Novi Sad.

出版信息

Med Pregl. 1990;43(7-8):301-4.

PMID:2098640
Abstract

A girl was described with an unusual combination of McCune-Albright's syndrome (polyostotic fibrotic dysplasia, hyperpigmentations on the skin and precocious puberty) with hyperthyroidism, hypophosphatemic-hyperphosphaturic rickets and acromegaly. Although the pathogenetic mechanism involved in the development of this endocrinopathy in this syndrome is not quite clear, the achieved results, as well as data of other researchers, suggest that the endocrinological disorders in this syndrome are the result of either an increased sensitivity of periphery endocrine organs or/and of an autonomous hyperfunction (similar to multiple endocrine adenomatosis).

摘要

一名女孩被描述患有McCune-Albright综合征(多骨纤维性发育不良、皮肤色素沉着和性早熟),同时伴有甲状腺功能亢进、低磷血症-高磷尿性佝偻病和肢端肥大症。尽管该综合征中这种内分泌病发生发展所涉及的发病机制尚不完全清楚,但已取得的结果以及其他研究人员的数据表明,该综合征中的内分泌紊乱是外周内分泌器官敏感性增加或/和自主功能亢进(类似于多发性内分泌腺瘤病)的结果。

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