使用正电子发射断层扫描技术探索梦睡眠与精神分裂症之间的关系。

Explorations in the relationship of dream sleep to schizophrenia using positron emission tomography.

作者信息

Weiler M A, Buchsbaum M S, Gillin J C, Tafalla R, Bunney W E

机构信息

Department of Psychiatry, University of Nebraska College of Medicine, Omaha.

出版信息

Neuropsychobiology. 1990;23(3):109-18. doi: 10.1159/000119435.

DOI:10.1159/000119435

PMID:2098666

Abstract

This study explored the relationship between rapid eye movement (REM) sleep and schizophrenia using positron emission tomography. Glucose use was compared between 49 schizophrenics, 30 awake controls and 12 controls in REM sleep. Assessment of the frequency and locations of brain areas showing significant differences suggested that REM did not resemble schizophrenia. Schizophrenics were between the higher awake controls and lower REM controls in corpus callosum glucose use. Hallucinating schizophrenics showed lower left caudate glucose use.

摘要

本研究使用正电子发射断层扫描技术探讨了快速眼动（REM）睡眠与精神分裂症之间的关系。对49名精神分裂症患者、30名清醒对照组和12名处于REM睡眠状态的对照组进行了葡萄糖利用情况的比较。对显示出显著差异的脑区频率和位置的评估表明，REM睡眠状态与精神分裂症不同。精神分裂症患者在胼胝体葡萄糖利用方面介于清醒对照组较高水平和REM睡眠对照组较低水平之间。出现幻觉的精神分裂症患者左侧尾状核葡萄糖利用较低。