Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T
Department of Neuro-Psychiatry, Aichi Medical College, Japan.
Neuropsychobiology. 1990;23(3):140-3. doi: 10.1159/000119441.
The plasma total biopterin and tetrahydrobiopterin (BH4) levels of 24 psychiatric patients were measured in the symptomatic phase, under no influence of psychotropic drugs as long as possible, and were compared with those of normal controls. The significant increase in total biopterin levels was observed only in the plasma of the patients with affective disorders or panic disorder in the depressive mood. A significant decrease in BH4 levels was observed only in the plasma of the patients with depression, and an increase in BH4 levels was observed only in the patients with hypomania. The changes of these biopterin levels in plasma could be a disease effect or a phase effect.
在症状期，尽可能在无精神药物影响的情况下，测量了24名精神科患者的血浆总生物蝶呤和四氢生物蝶呤（BH4）水平，并与正常对照组进行了比较。仅在患有情感障碍或处于抑郁情绪的惊恐障碍患者的血浆中观察到总生物蝶呤水平显著升高。仅在抑郁症患者的血浆中观察到BH4水平显著降低，而仅在轻躁狂症患者中观察到BH4水平升高。血浆中这些生物蝶呤水平的变化可能是疾病效应或阶段效应。
