Hashimoto R, Ozaki N, Ohta T, Kasahara Y, Kaneda N, Nagatsu T
Department of Psychiatry, Nagoya University School of Medicine, Japan.
Neuropsychobiology. 1988;19(2):61-3. doi: 10.1159/000118435.
The plasma biopterin levels of 13 patients with affective disorders were measured both in the symptomatic phase and in the remission phase, and under no influence of psychotropic drugs except lithium and/or carbamazepine by high-performance liquid chromatography with fluorescence detection, and were compared with those of normal controls. The biopterin levels of patients in the symptomatic phase were elevated significantly as compared with those of normal controls, and the elevation tended to be more pronounced in the hypomanic phase than in the depressive phase. In contrast, the biopterin levels of patients in remission were not different from those of normal controls.
采用高效液相色谱荧光检测法，在症状期和缓解期测量了13例情感障碍患者的血浆生物蝶呤水平，且测量时除锂盐和/或卡马西平外不受精神药物影响，并与正常对照组进行比较。与正常对照组相比，症状期患者的生物蝶呤水平显著升高，且轻躁狂期的升高往往比抑郁期更明显。相比之下，缓解期患者的生物蝶呤水平与正常对照组无差异。
