Lin J, Lu G, Jiang G
Institute of Basic Medical Sciences, CAMS, Beijing.
Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(3):145-8.
The opioid peptides leucine enkephalin (LENK) and methionine enkephalin (MENK) were investigated for their effect on the proliferative response of activated BALB/C mouse and Sprague-Dawley rat splenic lymphocytes in vitro. The results showed that LENK and MENK (1 x 10(-3) mg/ml to 1 x 10(-13) mg/ml) significantly suppressed the proliferative response of mouse lymphocytes to phytohemagglutinin (PHA) and enhanced the proliferation of rat lymphocytes at peptide concentrations similar to those effective in mice. It is proposed that endogenous ENKs play a neuroendocrine role between the central nervous system and the immune system.
研究了阿片肽亮氨酸脑啡肽（LENK）和甲硫氨酸脑啡肽（MENK）对体外活化的BALB/C小鼠和Sprague-Dawley大鼠脾淋巴细胞增殖反应的影响。结果表明，LENK和MENK（1×10⁻³mg/ml至1×10⁻¹³mg/ml）显著抑制小鼠淋巴细胞对植物血凝素（PHA）的增殖反应，并在与对小鼠有效的肽浓度相似的情况下增强大鼠淋巴细胞的增殖。有人提出内源性脑啡肽在中枢神经系统和免疫系统之间发挥神经内分泌作用。
