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[阿片受体刺激对体内淋巴细胞功能活性的影响]

[The effect of the stimulation of opioid receptors on lymphocyte functional activity in vivo].

作者信息

Kharkevich D D, Kadagidze Z G

出版信息

Biull Eksp Biol Med. 1989 Sep;108(9):315-6.

PMID:2558746
Abstract

With the aid of lymphocytes' spontaneous adhesion test and the reaction of blast transformation with phytohemagglutinin (PHA) the influence of met-enkephaline upon the functional activity of lymphocytes of healthy donors was studied in vitro. It was shown, that met-enkephaline stimulate lymphocyte spontaneous adhesion and the lymphocyte PHA-induced proliferative activity. The stimulating effects of met-enkephalin revealed in vitro were blocked by the opioid receptor blocker naloxone.

摘要

借助淋巴细胞自发黏附试验以及淋巴细胞与植物血凝素(PHA)的 blast 转化反应,在体外研究了甲硫氨酸脑啡肽对健康供体淋巴细胞功能活性的影响。结果表明,甲硫氨酸脑啡肽可刺激淋巴细胞自发黏附以及淋巴细胞PHA诱导的增殖活性。体外观察到的甲硫氨酸脑啡肽的刺激作用被阿片受体阻滞剂纳洛酮阻断。

相似文献

1
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Biull Eksp Biol Med. 1989 Sep;108(9):315-6.
2
[Importance of opiate receptor ligands in regulating lymphocyte proliferative activity].
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3
In vitro influence of enkephalins on the proliferative response of mouse and rat splenic lymphocytes to phytohemagglutinin.脑啡肽对小鼠和大鼠脾淋巴细胞对植物血凝素增殖反应的体外影响。
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Methionine-enkephalin stimulates in vitro proliferation of human peripheral lymphocytes via delta-opioid receptors.甲硫氨酸脑啡肽通过δ-阿片受体刺激人外周血淋巴细胞的体外增殖。
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