Shostak N A, Anokhin V N, Kazakova T V, Morozova E I, Zolkina I V, Voĭlokova R Ia
Revmatologiia (Mosk). 1990 Jul-Sep(3):27-31.
Results of clinico-genealogical and immunogenetic examination of 220 persons including 150 patients suffering from rheumatism and members of their families have been presented. The object of the examination was a B-cell marker carriership to be determined by means of monoclonic antibodies D8/17 with the use of the microlymphocytotoxic method. The marker carriership was detected in 96 per cent of probands-patients with rheumatism and in 40.3 per cent of their relatives and in 6.7 per cent of healthy individuals of the control group. A possible contribution of the B-cell marker to rheumatism liability was suggested. A further study of the role of the given marker in rheumatism has been found advisable.
本文呈现了对220人（包括150名风湿病患者及其家庭成员）进行临床系谱和免疫遗传学检查的结果。检查对象是通过使用微淋巴细胞毒性方法，借助单克隆抗体D8/17来确定B细胞标志物携带情况。在96%的风湿病先证者患者、40.3%的其亲属以及6.7%的对照组健康个体中检测到了该标志物携带情况。提示了B细胞标志物对患风湿病易感性可能的影响。已发现进一步研究该特定标志物在风湿病中的作用是可取的。
