Belman S, Troll W, Garte S J
Cancer Res. 1978 Sep;38(9):2978-82.
Basal levels of cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate were determined in mouse epidermis in vivo after a single topical treatment with the tumor promoter phorbol myristate acetate. No changes in cyclic adenosine 3':5'-monophosphate levels were found from 0 to 72 hr after treatment. A twofold increase in cyclic guanosine 3':5'-monophosphate was found 36 hr after treatment. This increase had subsided by 72 hr. The effect of phorbol myristate acetate on DNA, RNA, and protein synthesis in the epidermis of Ha/ICR mice was also measured.
在用肿瘤促进剂佛波酯肉豆蔻酸酯乙酸盐单次局部处理后，测定了小鼠表皮中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的基础水平。处理后0至72小时，未发现环磷酸腺苷水平有变化。处理后36小时，发现环磷酸鸟苷增加了两倍。到72小时时，这种增加已经消退。还测定了佛波酯肉豆蔻酸酯乙酸盐对Ha/ICR小鼠表皮中DNA、RNA和蛋白质合成的影响。
