佛波醇肉豆蔻酸酯乙酸酯对小鼠表皮中环核苷酸水平的影响。

Effect of phorbol myristate acetate on cyclic nucleotide levels in mouse epidermis.

作者信息

Belman S, Troll W, Garte S J

出版信息

Cancer Res. 1978 Sep;38(9):2978-82.

Abstract

Basal levels of cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate were determined in mouse epidermis in vivo after a single topical treatment with the tumor promoter phorbol myristate acetate. No changes in cyclic adenosine 3':5'-monophosphate levels were found from 0 to 72 hr after treatment. A twofold increase in cyclic guanosine 3':5'-monophosphate was found 36 hr after treatment. This increase had subsided by 72 hr. The effect of phorbol myristate acetate on DNA, RNA, and protein synthesis in the epidermis of Ha/ICR mice was also measured.

摘要

在用肿瘤促进剂佛波酯肉豆蔻酸酯乙酸盐单次局部处理后，测定了小鼠表皮中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的基础水平。处理后0至72小时，未发现环磷酸腺苷水平有变化。处理后36小时，发现环磷酸鸟苷增加了两倍。到72小时时，这种增加已经消退。还测定了佛波酯肉豆蔻酸酯乙酸盐对Ha/ICR小鼠表皮中DNA、RNA和蛋白质合成的影响。

相似文献

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Effect of phorbol myristate acetate on cyclic nucleotide levels in mouse epidermis.佛波醇肉豆蔻酸酯乙酸酯对小鼠表皮中环核苷酸水平的影响。

Cancer Res. 1978 Sep;38(9):2978-82.

2

The effect of the phorbol ester tumor promoters on the basal and catecholamine-stimulated levels of cyclic adenosine 3':5'-monophosphate in mouse skin and epidermis in vivo.佛波酯肿瘤启动子对小鼠皮肤和表皮中体内环磷酸腺苷（cAMP）基础水平及儿茶酚胺刺激水平的影响。

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Cancer Res. 1980 Feb;40(2):240-4.

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Effects of multiple phorbol myristate acetate treatments on cyclic nucleotide levels in mouse epidermis.多次佛波醇肉豆蔻酸酯乙酸酯处理对小鼠表皮中环状核苷酸水平的影响。

Biochem Biophys Res Commun. 1978 Sep 29;84(2):489-94. doi: 10.1016/0006-291x(78)90195-x.

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Cyclic nucleotide levels in rat embryo fibroblasts treated with tumor-promoting phorbol diester.用促癌佛波酯处理的大鼠胚胎成纤维细胞中的环核苷酸水平

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6

Diurnal variation in cyclic nucleotide levels in normal and phorbol myristate acetate treated mouse epidermis.正常及佛波醇肉豆蔻酸酯乙酸酯处理的小鼠表皮中环状核苷酸水平的昼夜变化。

J Invest Dermatol. 1980 Apr;74(4):224-5. doi: 10.1111/1523-1747.ep12541758.

7

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8

Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo.3-异丁基-1-甲基黄嘌呤和环核苷酸对12-O-十四烷酰佛波醇-13-乙酸酯诱导的小鼠表皮鸟氨酸脱羧酶活性的体内效应。

Cancer Res. 1981 Oct;41(10):3918-26.

9

Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas.佛波酯处理的小鼠皮肤表皮及乳头瘤中，环磷酸腺苷3':5'-单磷酸磷酸二酯酶活性增加。

Cancer Res. 1979 Jun;39(6 Pt 1):2036-40.

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Stimulation of the synthesis of mouse epidermal histones by tumor-promoting agents.肿瘤促进剂对小鼠表皮组蛋白合成的刺激作用。

Cancer Res. 1977 Dec;37(12):4584-9.

引用本文的文献

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Dissociation of tumour-promoter-induced effects on prostaglandin release, polyamine synthesis and cell proliferation of 3T3 cells.肿瘤启动子对3T3细胞前列腺素释放、多胺合成和细胞增殖诱导作用的解离。

Biochem J. 1981 Mar 15;194(3):975-82. doi: 10.1042/bj1940975.

2

Tumor promoters specifically and reversibly disturb development and behavior of Caenorhabditis elegans.肿瘤启动子特异性且可逆地干扰秀丽隐杆线虫的发育和行为。

J Cancer Res Clin Oncol. 1982;104(1-2):81-7. doi: 10.1007/BF00402056.

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