肿瘤启动子特异性且可逆地干扰秀丽隐杆线虫的发育和行为。
Tumor promoters specifically and reversibly disturb development and behavior of Caenorhabditis elegans.
作者信息
Miwa J, Tabuse Y, Furusawa M, Yamasaki H
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):81-7. doi: 10.1007/BF00402056.
Abstract
The effect of phorbol ester tumor promoters on the development and behavior of a free-living soil nematode, Caenorhabditis elegans, was studied. When young developing C. elegans were grown on E. coli-seeded agar with low concentrations (0.1 microgram/ml) of 12-0-tetradecanoyl-phorbol-13-acetate or phorbol-12,13-didecanoate, their growth was arrested. These tumor promoters reduced the brood size when gravid adults were treated and caused uncoordinated movement in animals treated at any stage of development. The effects of these tumor promoters on nematode development and behavior were partially reversible. The nonpromoting derivatives phorbol and 4 alpha-phorbol-12,13-didecanoate showed no effect on the animals.
摘要
研究了佛波酯肿瘤启动子对自由生活的土壤线虫秀丽隐杆线虫发育和行为的影响。当处于发育阶段的幼年秀丽隐杆线虫在接种了大肠杆菌的琼脂上，用低浓度（0.1微克/毫升）的12-0-十四烷酰佛波醇-13-乙酸酯或佛波醇-12,13-二十二酸酯培养时，它们的生长会停滞。当妊娠成虫接受处理时，这些肿瘤启动子会减少产卵量，并导致在发育任何阶段接受处理的动物出现不协调运动。这些肿瘤启动子对线虫发育和行为的影响部分是可逆的。非启动衍生物佛波醇和4α-佛波醇-12,13-二十二酸酯对动物没有影响。
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