Basov P V, Prokhorov N N, Spesivtsev O G
Vrach Delo. 1990 Nov(11):20-2.
The content of cortisol was examined radioimmunologically in 60 patients with pulmonary tuberculosis with the purpose to evaluate the inactivating effect of rifampicin on exogenous glucocorticoid hormones. Separate administration of hormones and rifampicin did not effect changes of endogenous cortisol indicating increased metabolism of glucocorticosteroids. Separate administration of hormones and rifampicin does not allow to avoid the inactivating effect of rifampicin on exogenous glucocorticosteroid hormones. Rifampicin did not change the level of endogenous cortisol.
采用放射免疫法检测了60例肺结核患者的皮质醇含量，目的是评估利福平对外源性糖皮质激素的灭活作用。分别给予激素和利福平并不影响内源性皮质醇的变化，提示糖皮质激素的代谢增加。分别给予激素和利福平并不能避免利福平对外源性糖皮质激素的灭活作用。利福平并未改变内源性皮质醇水平。
