Nocke-Finck L, Breuer H, Reimers D
J Clin Chem Clin Biochem. 1980 Dec;18(12):897-9.
It has been shown previously that the biosynthesis and metabolism of oestrogens is affected by rifampicin. The present study was undertaken to investigate if rifampicin may also influence the plasma concentrations of testosterone and cortisol. Five male patients suffering from tuberculosis received rifampicin or streptomycin. During treatment with rifampicin testosterone concentrations were significantly elevated as compared to control conditions; this increase was found in the morning (8.00 h) as well as in the afternoon (16.30 h). When the same patients were treated with streptomycin, only irregular changes of testosterone concentrations were observed. The blood level of cortisol was increased in two patients, but unchanged in three patients who were treated with rifampicin. No changes at all were detected in patients under treatment with streptomycin. The results presented here show that rifampicin -- in contrast to streptomycin -- influences the biosynthesis of testosterone and possibly also that of cortisol.
先前已有研究表明，利福平会影响雌激素的生物合成和代谢。本研究旨在调查利福平是否也会影响睾酮和皮质醇的血浆浓度。五名患有结核病的男性患者接受了利福平或链霉素治疗。在使用利福平治疗期间，与对照情况相比，睾酮浓度显著升高；这种升高在上午（8:00）和下午（16:30）均被发现。当相同的患者接受链霉素治疗时，仅观察到睾酮浓度的不规则变化。两名接受利福平治疗的患者皮质醇血水平升高，但三名患者未变。接受链霉素治疗的患者未检测到任何变化。此处呈现的结果表明，与链霉素不同，利福平会影响睾酮的生物合成，可能还会影响皮质醇的生物合成。
