Yao Y M, Hou G P, Wang M Y, Cui Z R, Cai F Q
Department of Microbiology and Immunology, Xinxiang Medical College.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1990;8(4):302-4.
This paper reports that tumor necrosis serum (TNS) containing tumor necrosis factor (TNF) could inhibit Plasmodium falciparum in vitro. TNS was obtained from rabbits given macrophage-activating agent Mycobacterium tuberculosis (BCG) followed by intravenous administration of bacterial endotoxin (LPS). The results showed that TNS dilutions of 1:3, 1:6 and 1:12 could induce disappearance of Plasmodium falciparum (P less than 0.05) after being cultured 6 hours. TNS decreased red blood cell infective rate of the parasites as compared with the control (P less than 0.05) after 12 hours' cultivation. TNS of 1:3 dilution had further effect at 24 hours (P less than 0.05). Morphological observations showed that the growth of schizonts was retarded and abnormal merozoites were found.
本文报道，含有肿瘤坏死因子（TNF）的肿瘤坏死血清（TNS）在体外可抑制恶性疟原虫。TNS是从先给予巨噬细胞激活剂结核分枝杆菌（卡介苗），随后静脉注射细菌内毒素（LPS）的兔子体内获得的。结果显示，1:3、1:6和1:12的TNS稀释液在培养6小时后可导致恶性疟原虫消失（P<0.05）。培养12小时后，与对照组相比，TNS降低了疟原虫的红细胞感染率（P<0.05）。1:3稀释度的TNS在24小时时具有进一步的作用（P<0.05）。形态学观察表明，裂殖体的生长受到抑制，并发现了异常的裂殖子。
