Henderson W G, Tourtellotte W W, Potvin A R, Rose A S
Clin Pharmacol Ther. 1978 Aug;24(2):146-53. doi: 10.1002/cpt1978242146.
From 1965 to 1968 a multicenter (USA) clinical trial was conducted to compare ACTH with placebo for the treatment of multiple sclerosis patients in a stage of acute exacerbation. Of seven evaluation systems which were used, one was a quantitative neurological examination. In this report, the quantitative neurological data have been re-evaluated using a transformation of the data which express patient scores in terms of a percentage of age- and sex-matched normal function followed by a reduction of the data into composite neurological functions vs time. The results support the positive findings of previous reports. In addition, the methodology helps to simplify the therapists' task of interpreting results by enabling him to determine how near normal function the patient came following the treatment trial.
1965年至1968年，美国进行了一项多中心临床试验，比较促肾上腺皮质激素（ACTH）与安慰剂对处于急性加重期的多发性硬化症患者的治疗效果。在使用的七个评估系统中，有一个是定量神经学检查。在本报告中，对定量神经学数据进行了重新评估，方法是对数据进行转换，以年龄和性别匹配的正常功能百分比来表示患者得分，然后将数据归纳为综合神经功能与时间的关系。结果支持了先前报告中的阳性发现。此外，该方法有助于简化治疗师解释结果的任务，使他能够确定患者在治疗试验后功能恢复到接近正常的程度。
