Ternisien C, Ollivier V, Chollet-Martin S, de Prost D
INSERM U294, CHU X.-Bichat, Paris, France.
Nouv Rev Fr Hematol (1978). 1990;32(5):373-5.
Monocytes can play a role in the activation of coagulation via increased procoagulant activity (PCA). We investigated the level of monocyte PCA in 19 patients with systemic lupus erythematosus (SLE), given the high rate of thrombotic events in this condition. 9 of these subjects also presented the lupus anticoagulant (LA). The PCA generated by patient monocytes was significantly higher than control values and was identified as tissue factor-like. Serum from both groups of patients (i.e. SLE and SLE + LA) stimulated the generation of PCA by control monocytes. By contrast, purified IgG from both patient groups had the same effect as control IgG on PCA generation by control monocytes. The nature of the stimulating agent in the serum was not identified. In conclusion, increased monocyte PCA may account for the increased incidence of thrombosis in SLE patients, although other, superimposed, factors would appear to exist in SLE + LA patients, given the higher incidence of thrombosis in this subgroup.
单核细胞可通过增强促凝血活性（PCA）在凝血激活过程中发挥作用。鉴于系统性红斑狼疮（SLE）患者血栓形成事件发生率较高，我们对19例SLE患者的单核细胞PCA水平进行了研究。其中9名受试者还存在狼疮抗凝物（LA）。患者单核细胞产生的PCA显著高于对照值，且被鉴定为组织因子样。两组患者（即SLE和SLE + LA）的血清均可刺激对照单核细胞产生PCA。相比之下，两组患者的纯化IgG对对照单核细胞PCA生成的作用与对照IgG相同。血清中刺激剂的性质尚未确定。总之，单核细胞PCA增加可能是SLE患者血栓形成发生率增加的原因，不过鉴于SLE + LA亚组中血栓形成发生率更高，SLE + LA患者似乎还存在其他叠加因素。
