Matheus M T, Hetem S, Guimarães Neto O M, da Sliveira Z V
Faculdade de Odontologia-UNESP.
Rev Odontol UNESP. 1990;19(1):41-9.
Thirty six female mice were injected on the 12th day of the gestational period with 0.2 ml of distilled water (control group) or of an acqueous solution containing either 30 mg/Kg or 50 mg/Kg of body weight of cyclophosphamide (treated group). The animal were killed at 24, 48, 72, 96 and 120 hours after the injection and 3 days after birth. It was verified that cyclophosphamide interferes on the tooth germ development and that this effect is in directly ratio of the doses used.
在妊娠期第12天，给36只雌性小鼠注射0.2毫升蒸馏水（对照组）或含有每千克体重30毫克或50毫克环磷酰胺的水溶液（处理组）。在注射后24、48、72、96和120小时以及出生后3天处死动物。证实环磷酰胺会干扰牙胚发育，且这种影响与所用剂量成正比。
