Warshaw J B
Department of Pediatrics, Yale School of Medicine, New Haven, Conn.
Dev Pharmacol Ther. 1990;15(3-4):153-8. doi: 10.1159/000457639.
Fetal growth is regulated by an interplay of genetic and environmental factors. Fetuses with growth restriction secondary to decreased nutritional supply exhibit maturation whereas hyperglycemic fetuses of diabetic mothers show delayed lung and placental maturation. Membranes from fetuses of diabetics have a decrease in epidermal-growth-factor (EGF) binding, whereas EGF binding is increased in lung and placenta of growth-restricted fetuses. These results suggest that the EGF receptor is responsive to altered nutritional states and may be important to substrate flow to the fetus.
胎儿生长受遗传和环境因素的相互作用调节。因营养供应减少而生长受限的胎儿表现出成熟，而糖尿病母亲的高血糖胎儿则表现出肺和胎盘成熟延迟。糖尿病母亲胎儿的胎膜表皮生长因子（EGF）结合减少，而生长受限胎儿的肺和胎盘中EGF结合增加。这些结果表明，EGF受体对营养状态的改变有反应，可能对底物流向胎儿很重要。
