博尔纳病病毒诱导的Lewis大鼠视网膜炎——一种免疫介导的视网膜病变。

Borna disease virus-induced retinitis in Lewis rats--an immune-mediated retinopathy.

作者信息

Geiss V, Frese K, Morales J A, Ojok L, Herzog S

机构信息

Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen.

出版信息

Lens Eye Toxic Res. 1990;7(3-4):741-51.

PMID:2100191

Abstract

Borna disease virus (BDV) infection, naturally occurring in horses and sheep induces a mononuclear retinitis and meningoencephalitis in adult Lewis rats. In the pathogenesis a virus-specific cell mediated immune reaction presumably of delayed hypersensitivity type is operative. Corresponding to the encephalitic lesions a progressive retinitis with loss of the first and second retinal neuron develops. The inflammatory response is characterized by predominance of macrophages in the early phase of infection followed by distinct plasmacellular infiltration. Immunosuppressed and immuno-incompetent rats do not develop retinal lesions after intracerebral inoculation. Thus similar as in the brain probably virus specific immunopathological reactions play a crucial role in the pathogenesis of BDV-induced retinitis in Lewis rats.

摘要

博尔纳病病毒（BDV）感染自然发生于马和绵羊，可在成年Lewis大鼠中诱发单核细胞性视网膜炎和脑膜脑炎。在发病机制中，可能是迟发型超敏反应类型的病毒特异性细胞介导免疫反应起作用。与脑部病变相对应，会出现第一和第二视网膜神经元丧失的进行性视网膜炎。炎症反应的特征是在感染早期巨噬细胞占优势，随后是明显的浆细胞浸润。免疫抑制和免疫功能不全的大鼠在脑内接种后不会出现视网膜病变。因此，与在脑部情况类似，病毒特异性免疫病理反应可能在Lewis大鼠BDV诱导的视网膜炎发病机制中起关键作用。