Hugosson J, Grenabo L, Hedelin H, Pettersson S, Tarfusser I
Department of Urology, Sahlgren's Hospital, Göteborg, Sweden.
Urol Res. 1990;18(6):413-7. doi: 10.1007/BF00297375.
To Study how the composition of urine influences urease-induced crystallization, human urine samples were incubated with urease and the subsequent precipitation measured. Beside the pH increase, the urinary content of magnesium and calcium had profound effects on the precipitation of magnesium ammonium phosphate and calcium phosphate, respectively. Urine phosphate, ammonium and osmolarity had no direct effects on the precipitation. Among the urine components with potential inhibitory properties, only albumin was found to be correlated with such an effect. This inhibitory activity was especially influential in urines with high calcium and magnesium levels. These findings suggest that the composition of urine could also influence the formation of stones consisting of magnesium ammonium phosphate and calcium phosphate.
为研究尿液成分如何影响脲酶诱导的结晶，将人尿液样本与脲酶一起孵育，并测量随后的沉淀情况。除了pH值升高外，尿液中镁和钙的含量分别对磷酸镁铵和磷酸钙的沉淀有深远影响。尿液中的磷酸盐、铵和渗透压对沉淀没有直接影响。在具有潜在抑制特性的尿液成分中，仅发现白蛋白与这种影响相关。这种抑制活性在钙和镁含量高的尿液中尤其显著。这些发现表明，尿液成分也可能影响由磷酸镁铵和磷酸钙组成的结石的形成。
