Tudor A M, Melia C D, Binns J S, Hendra P J, Church S, Davies M C
Department of Pharmaceutical Sciences, University of Nottingham, UK.
J Pharm Biomed Anal. 1990;8(8-12):717-20. doi: 10.1016/0731-7085(90)80109-3.
Near infrared Fourier-transform (FT) Raman spectroscopy is shown to be a useful spectroscopic tool for the molecular structural analysis of drugs and biomedical polymers. The technique has been applied to the non-invasive investigation of the hydrolytic degradation of a biodegradable polymer in water over a period of 15 days and to the analysis of a drug within a polymer vehicle over a wide drug concentration range. This work demonstrates the potential value of FT Raman spectroscopy in the field of pharmaceutical science.
近红外傅里叶变换（FT）拉曼光谱被证明是一种用于药物和生物医学聚合物分子结构分析的有用光谱工具。该技术已应用于对一种可生物降解聚合物在水中15天的水解降解进行非侵入性研究，以及在很宽的药物浓度范围内对聚合物载体中的药物进行分析。这项工作证明了FT拉曼光谱在制药科学领域的潜在价值。
