Tudor A M, Church S J, Hendra P J, Davies M C, Melia C D
Department of Pharmaceutical Sciences, University of Nottingham, U.K.
Pharm Res. 1993 Dec;10(12):1772-6. doi: 10.1023/a:1018934417124.
We analyzed binary mixtures of polymorphs A and B of chlorpropamide ((1-[4-chlorobenzenesulphonyl]-3-propyl urea)) by near-infrared Fourier transform Raman spectroscopy (FTRS). The individual polymorphs were prepared and characterized by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) microscopy, and physical appearance. The FTR spectra of the two polymorphs showed distinct differences which result from "crystal splitting" effects. A series of 13 different mixtures of polymorph A and B was prepared by geometric mixing and their FTR spectra statistically analysed by factor analysis programming. Predictions of the A/B polymorphic composition of mixtures were made and compared with the theoretical values. The results demonstrate that FTRS combined with factor analysis programming may be successfully applied to the in situ monitoring of the A/B polymorphic nature of a chlorpropamide sample.
我们通过近红外傅里叶变换拉曼光谱法（FTRS）分析了氯磺丙脲（(1-[4-氯苯磺酰基]-3-丙基脲)）多晶型物A和B的二元混合物。制备了各个多晶型物，并通过差示扫描量热法（DSC）、傅里叶变换红外（FT-IR）显微镜和物理外观进行了表征。两种多晶型物的FTR光谱显示出明显差异，这是由“晶体分裂”效应导致的。通过几何混合制备了一系列13种不同的多晶型物A和B的混合物，并通过因子分析程序对其FTR光谱进行了统计分析。对混合物的A/B多晶型组成进行了预测，并与理论值进行了比较。结果表明，FTRS结合因子分析程序可成功应用于氯磺丙脲样品A/B多晶型性质的原位监测。
