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受体调节与靶细胞反应：卵巢黄体细胞研究

Receptor regulation and target cell responses: studies in the ovarian luteal cell.

作者信息

Harwood J P, Conti M, Conn P M, Dufau M L, Catt K J

出版信息

Mol Cell Endocrinol. 1978 Jul-Aug;11(2):121-35. doi: 10.1016/0303-7207(78)90001-1.

DOI:10.1016/0303-7207(78)90001-1
PMID:210062
Abstract

Studies of hormone-induced 'desensitization' in the luteinized rat ovary show that changes in receptor number and adenylate cyclase at the cell surface result in an altered biological effect of luteinizing hormone on progesterone production. The sensitivity of these effects to changes in gonadotropin levels suggests that receptor turnover or processing is involved in the normal mechanism of hormone action.

摘要

对黄体化大鼠卵巢中激素诱导的“脱敏”研究表明，细胞表面受体数量和腺苷酸环化酶的变化导致促黄体生成素对孕酮生成的生物学效应发生改变。这些效应对促性腺激素水平变化的敏感性表明，受体周转或加工参与了激素作用的正常机制。

相似文献

1
Receptor regulation and target cell responses: studies in the ovarian luteal cell.受体调节与靶细胞反应：卵巢黄体细胞研究
Mol Cell Endocrinol. 1978 Jul-Aug;11(2):121-35. doi: 10.1016/0303-7207(78)90001-1.
2
Effect of gonadotropin-induced receptor regulation on biological responses of isolated rat luteal cells.促性腺激素诱导的受体调节对离体大鼠黄体细胞生物学反应的影响。
J Biol Chem. 1977 Dec 25;252(24):8869-74.
3
Luteal desensitization: hormonal regulation of LH receptors, adenylate cyclase and steroidogenic responses in the luteal cell.黄体脱敏：黄体细胞中促黄体生成素受体、腺苷酸环化酶和类固醇生成反应的激素调节。
Adv Exp Med Biol. 1979;112:647-62. doi: 10.1007/978-1-4684-3474-3_72.
4
Luteal cell receptor content for prolactin (PRL) and luteinizing hormone (LH): regulation by LH and PRL.黄体细胞催乳素（PRL）和促黄体生成素（LH）的受体含量：LH和PRL的调节作用
Endocrinology. 1976 Dec;99(6):1571-81. doi: 10.1210/endo-99-6-1571.
5
Inhibition of HCG-induced cyclic AMP accumulation and steroidogenesis in rat luteal cells by an LHRH agonist.促黄体生成素释放激素激动剂对大鼠黄体细胞中促性腺激素释放激素诱导的环磷酸腺苷积累和类固醇生成的抑制作用。
J Steroid Biochem. 1981 Mar;14(3):239-42. doi: 10.1016/0022-4731(81)90131-x.
6
Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells.棉酚对培养的牛黄体细胞中人类绒毛膜促性腺激素（hCG）诱导的孕酮分泌的抑制作用。
Life Sci. 1990;47(5):407-14. doi: 10.1016/0024-3205(90)90298-6.
7
Gonadotropin receptors in rat ovarian tissue: III. Binding sites for luteinizing hormone and differentiation of granulosa cells to luteal cells.大鼠卵巢组织中的促性腺激素受体：III. 促黄体生成素的结合位点及颗粒细胞向黄体细胞的分化
Endocrinology. 1977 Sep;101(3):898-910. doi: 10.1210/endo-101-3-898.
8
Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3',5' cyclic monophosphate formation.有证据表明，达那唑在促性腺激素受体相互作用和3',5'-环磷酸腺苷形成的远端位点抑制促性腺激素诱导的卵巢类固醇生成。
Am J Obstet Gynecol. 1980 Feb 15;136(4):524-30. doi: 10.1016/0002-9378(80)90683-3.
9
Estradiol suppression of luteinizing hormone (LH)/human chorionic gonadotropin receptors and LH-sensitive adenylyl cyclase without decreased adenosine 3',5'-monophosphate content in rabbit corpora lutea.雌二醇对兔黄体中促黄体生成素（LH）/人绒毛膜促性腺激素受体及LH敏感性腺苷酸环化酶的抑制作用，而不降低腺苷3'，5'-单磷酸含量。
Endocrinology. 1986 May;118(5):2016-23. doi: 10.1210/endo-118-5-2016.
10
Studies on the mechanism of PGF2alpha and gonadotropin interactions on LH receptor function in corpora lutea during luteolysis.黄体溶解过程中PGF2α与促性腺激素对黄体中LH受体功能相互作用机制的研究。
Adv Prostaglandin Thromboxane Res. 1976;2:655-66.

引用本文的文献

1
Secretin and VIP-stimulated adenylate cyclase from rat heart. II. Impairment in spontaneous hypertension.大鼠心脏中促胰液素和血管活性肠肽刺激的腺苷酸环化酶。II. 自发性高血压中的损伤
Pflugers Arch. 1980 Dec;389(1):29-35. doi: 10.1007/BF00587925.
2
Electron-microscopic and morphometric study of vesiculation in the epithelial cell layer of the toad urinary bladder. Effect of antidiuretic hormone.蟾蜍膀胱上皮细胞层中囊泡形成的电子显微镜及形态测量学研究。抗利尿激素的作用。
Cell Tissue Res. 1982;225(3):619-31. doi: 10.1007/BF00214808.
3
Desensitization of steroidogenesis in cultured Leydig tumor cells: role of cholesterol.
培养的睾丸间质细胞瘤细胞中类固醇生成的脱敏作用：胆固醇的作用
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7796-800. doi: 10.1073/pnas.79.24.7796.
4
Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis.培养的睾丸间质细胞瘤细胞对促性腺激素脱敏涉及促性腺激素受体的丧失和类固醇生成能力的降低。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6309-13. doi: 10.1073/pnas.78.10.6309.
5
Regulation of ovarian LH/HCG receptors in pregnant rats.妊娠大鼠卵巢促黄体生成素/人绒毛膜促性腺激素受体的调节
Arch Gynecol. 1980;229(4):259-64. doi: 10.1007/BF02108576.
6
Aggregation of luteinizing hormone receptors in granulosa cells: a possible mechanism of desensitization to the hormone.促黄体生成素受体在颗粒细胞中的聚集：一种对该激素脱敏的可能机制。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3440-4. doi: 10.1073/pnas.77.6.3440.
7
Desensitization of the beta-adrenoceptor-adenylate cyclase system of immature erythrocytes by in-vivo treatment of rats with isoprenaline.通过用异丙肾上腺素对大鼠进行体内治疗使未成熟红细胞的β-肾上腺素能受体-腺苷酸环化酶系统脱敏。
Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):294-301. doi: 10.1007/BF00501309.
8
Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.表皮生长因子对人癌细胞A-431中胞饮作用的快速刺激。
J Cell Biol. 1979 Oct;83(1):82-90. doi: 10.1083/jcb.83.1.82.
9
Regulation of primate testicular luteinizing hormone receptors and steroidogenesis.灵长类动物睾丸促黄体生成素受体与类固醇生成的调节。
J Clin Invest. 1979 Oct;64(4):1070-3. doi: 10.1172/JCI109545.