Briel D
Sektion Biowissenschaften der Universität Leipzig.
Pharmazie. 1990 Dec;45(12):895-9.
Dicyanketendithiolae reacts with equimolar amounts of halogenmethans, substituted with electron withdrawing groups, to give thiophene-2-thiolates. These compounds are used for the preparation of thieno[2,3-b]thiophenes, including several functional groups in 2- and 5-position. Anellation of 1,3-oxazin-, pyrimidin-, 1,2,3-triazin- or 1,4-oxazepin-cycles give hitherto unknown tri- and tetracyclic ring systems. Some of synthetised compounds show biological activity.
二氰基二硫醇盐与等摩尔量的被吸电子基团取代的卤代甲烷反应，生成噻吩 - 2 - 硫醇盐。这些化合物用于制备噻吩并[2,3 - b]噻吩，其在2位和5位包含几个官能团。1,3 - 恶嗪环、嘧啶环、1,2,3 - 三嗪环或1,4 - 恶氮杂环庚烷环的并环生成了迄今未知的三环和四环环系。一些合成的化合物具有生物活性。
