Mizinska-Boevska Y, Tsocheva N, Polyakova-Krusteva O, Krustev L
Central Laboratory of Helminthology, Bulgarian Academy of Sciences, Sofia.
Acta Vet Hung. 1990;38(1-2):69-75.
The ultrastructure of peritoneal macrophages of rats with chronic fascioliasis and the carcinogenic effect of diethylnitrosamine (DENA) were studied. The phagocytic activity of macrophages on Staphylococcus aureus were examined in its dynamics (in the 1st, 5th and 24th h). The ultrastructural changes of the macrophages were the most pronounced in animals injected eight times with DENA and the weakest in the group of animals infected twice with Fasciola hepatica. As to the phagocytic activity of the macrophages the following events were observed: attraction and adhesion of the bacterial cells to the surface of the macrophages, their inclusion in phagosomes; partial to full lysis of the bacteria; and formation of residual bodies. The phagocytosis was the most active in macrophages obtained from animals infected twice with Fasciola hepatica and the weakest in those from the DENA-treated animals.
研究了慢性片形吸虫病大鼠腹膜巨噬细胞的超微结构以及二乙基亚硝胺（DENA）的致癌作用。检测了巨噬细胞对金黄色葡萄球菌的吞噬活性动态变化（第1、5和24小时）。巨噬细胞的超微结构变化在八次注射DENA的动物中最为明显，而在两次感染肝片吸虫的动物组中最为轻微。关于巨噬细胞的吞噬活性，观察到以下事件：细菌细胞吸附和黏附于巨噬细胞表面，被纳入吞噬体；细菌部分至完全溶解；以及残余体的形成。吞噬作用在两次感染肝片吸虫的动物所获得的巨噬细胞中最为活跃，而在接受DENA处理的动物所获得的巨噬细胞中最为微弱。
