Morato G S, Rosas A M, Bittencourt S C, Chacon A M
Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
Braz J Med Biol Res. 1990;23(8):701-3.
The present study analyzes the effect of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were treated with ethanol (2 g kg-1 day-1, ip) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treated simultaneously with ethanol plus indomethacin (5 mg/kg, ip, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indomethacin prevented the development of tolerance to the diuretic effect of ethanol but had no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol.
本研究分析了吲哚美辛对乙醇利尿作用耐受性发展的影响。雄性Wistar大鼠在4周内接受乙醇（2克/千克/天，腹腔注射）治疗，并每周评估乙醇对利尿的影响。治疗3周后检测到对乙醇利尿作用有显著耐受性。然而，同时用乙醇加吲哚美辛（5毫克/千克，腹腔注射，隔日一次）治疗的大鼠即使在治疗4周后也未表现出对乙醇的耐受性。吲哚美辛可防止对乙醇利尿作用耐受性的发展，但对利尿本身无影响，这一事实表明前列腺素在乙醇耐受性机制中起重要作用。
