非裔古巴人群中-α3.7地中海贫血缺失的频率。
Frequency of the -alpha 3.7 thalassemia deletion in the non-white Cuban population.
作者信息
Martinez G, Ferreira R, Hernandez A, Di Rienzo A, Felicetti L, Colombo B
机构信息
Instituto de Hematologia e Inmunologia, La Habana, Cuba.
出版信息
Gene Geogr. 1990 Aug;4(2):65-9.
PMID:2101253
Abstract
DNA analysis of the alpha-globin gene cluster showed that the frequency of the -alpha 3.7 deletion in the non-white cuban population is about 0.12, in agreement with a 47% admixture of the original African slaves introduced in the island. In the S-S homozygotes the frequency is slightly higher (.18), probably due to a selective advantage produced by the presence of alpha-thalassemia in sickle cell patients.
摘要
对α-珠蛋白基因簇的DNA分析表明，在非白人古巴人群中，-α3.7缺失的频率约为0.12，这与该岛最初引入的非洲奴隶47%的混合比例相符。在镰状细胞纯合子中，该频率略高（0.18），这可能是由于镰状细胞病患者中存在α地中海贫血所产生的选择优势。
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