Sakai H, Miyakawa H, Daiguji Y, Hasumura Y, Marumo F, Negishi T, Maeda M, Kusafuka K, Hatakeyama S
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Jpn J Med. 1990 Nov-Dec;29(6):633-6. doi: 10.2169/internalmedicine1962.29.633.
A 73-year-old man developed graft-versus-host disease (GVHD) after blood transfusion; he developed hepatitis, fever, rash, and pancytopenia. Although similar cases have been previously reported, the spectra of their liver injury was not clarified. The clinical and pathological findings of this case and a review of earlier reports suggest a possible predominance of hepatocellular injury in cases of GVHD after blood transfusion, which is in contrast to the prevalence of cholestatic liver disease in GVHD following bone marrow transplantation.
一名73岁男性在输血后发生移植物抗宿主病（GVHD）；他出现了肝炎、发热、皮疹和全血细胞减少。尽管此前已有类似病例报道，但肝损伤的范围尚未明确。该病例的临床和病理表现以及对早期报告的回顾表明，输血后GVHD病例中可能以肝细胞损伤为主，这与骨髓移植后GVHD中胆汁淤积性肝病的患病率形成对比。
