Nozaki S, Yajima Y, Iijima M, Fujisawa R
Nihon Hifuka Gakkai Zasshi. 1989 Feb;99(2):149-54.
Graft-versus-host disease (GVDH)-like syndrome occurred in a 45 year-old man with duodenal ulcer who had received a transfusion of 8 units of packed red blood cells. Clinical features included high fever, macropapular rash, hepatic dysfunction, pancytopenia and, finally, fatal septicemia. A skin biopsy obtained from the chest revealed satellite cell necrosis of epidermal cells, mononuclear cell infiltrate of the upper dermis and epidermis, and vacuolar degeneration of basal cells. Autopsy bone marrow was aplastic. The occurrence of GVHD in immunologically normal individuals following blood transfusion is extremely rare.
一名患有十二指肠溃疡的45岁男性在输注8单位浓缩红细胞后出现了类似移植物抗宿主病（GVDH）的综合征。临床特征包括高热、斑丘疹、肝功能障碍、全血细胞减少，最终发展为致命的败血症。胸部皮肤活检显示表皮细胞卫星状细胞坏死、真皮上层和表皮单核细胞浸润以及基底细胞空泡变性。尸检发现骨髓再生障碍。免疫功能正常的个体在输血后发生移植物抗宿主病极为罕见。
