Nasraoui A, Pocidalo J J
Institut National de Nutrition de Tunis, Bab Saâdoun.
Arch Inst Pasteur Tunis. 1990 Jan-Apr;67(1-2):39-45.
Induction by phenobarbital and 3-methylcholanthrene of enzymes metabolizing xenobiotics in rat exposed 55 hrs to hyperoxia, is maintained. The level of microsomal pulmonary and hepatic cytochrome P-450 has even increased. In rat protected against a hyperoxia 6 days, stimulation of UDP-glucuronosyltransferase does not decrease and malondialdehydes level does not change. These results assume the probable role of enzymatic induction in the tolerance to hyperoxia induced in rast by treatment with phenobarbital and 3- methylcholanthrene.
在暴露于高氧环境55小时的大鼠中，苯巴比妥和3-甲基胆蒽对代谢外源性物质的酶的诱导作用得以维持。肺和肝微粒体细胞色素P-450的水平甚至有所增加。在对高氧有6天防护作用的大鼠中，UDP-葡萄糖醛酸基转移酶的刺激作用并未降低，丙二醛水平也未改变。这些结果表明，酶诱导可能在苯巴比妥和3-甲基胆蒽处理诱导的大鼠对高氧的耐受性中发挥作用。
