Boon M E, de Graaff Guilloud J C, Rietveld W J, Wijsman-Grootendorst A
Leiden Cytology and Pathology Laboratory, The Netherlands.
Cytopathology. 1990;1(4):201-10. doi: 10.1111/j.1365-2303.1990.tb00348.x.
The effect of regular 3-yearly screening over a period of 12 years, on the incidence of cervical cancer in 25,000 women aged 35-54 years, is examined. The rate of squamous cell carcinoma decreased from 0.38 per 1000 women in the first round to zero in the fourth round. Similarly, the rate of carcinoma in situ declined from 1.69 per 1000 women in the first round to 0.35 per 1000 in the fourth round. The rates of severe dysplasia showed no decline. Cytologic under diagnosis of carcinoma-in-situ and cervical carcinoma increased with each round. Widowed and divorced women and those living in urban areas were identified as high risk groups.
研究了在12年期间对25000名35至54岁女性进行定期每3年一次筛查对宫颈癌发病率的影响。鳞状细胞癌的发病率从第一轮每1000名女性中的0.38例降至第四轮的零例。同样，原位癌的发病率从第一轮每1000名女性中的1.69例降至第四轮的每1000名中的0.35例。重度发育异常的发病率没有下降。每一轮中，原位癌和宫颈癌的细胞学漏诊率都有所增加。丧偶和离异女性以及居住在城市地区的女性被确定为高危人群。
