• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Partial reaction of prolyl hydroxylase. (Gly-PRO-Ala)n stimulates alpha-ketoglutarate decarboxylation without prolyl hydroxylation.

作者信息

Rao N V, Adams E

出版信息

J Biol Chem. 1978 Sep 25;253(18):6327-30.

PMID:210178
Abstract
摘要

相似文献

1
Partial reaction of prolyl hydroxylase. (Gly-PRO-Ala)n stimulates alpha-ketoglutarate decarboxylation without prolyl hydroxylation.脯氨酰羟化酶的部分反应。(甘氨酸-脯氨酸-丙氨酸)n刺激α-酮戊二酸脱羧而不发生脯氨酰羟化。
J Biol Chem. 1978 Sep 25;253(18):6327-30.
2
Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of alpha-ketoglutarate.脯氨酰羟化酶半反应：α-酮戊二酸的肽基脯氨酰非依赖性脱羧反应。
Proc Natl Acad Sci U S A. 1978 May;75(5):2145-9. doi: 10.1073/pnas.75.5.2145.
3
Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit.蛋白质羟基化：脯氨酰4-羟化酶，一种具有四种共底物和一个多功能亚基的酶。
FASEB J. 1989 Mar;3(5):1609-17.
4
Interaction of prolyl 4-hydroxylase with synthetic peptide substrates. A conformational model for collagen proline hydroxylation.脯氨酰4-羟化酶与合成肽底物的相互作用。胶原蛋白脯氨酸羟化的构象模型。
J Biol Chem. 1991 Feb 15;266(5):2852-8.
5
Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme.脯氨酰羟化酶对（脯氨酸-脯氨酸-甘氨酸）5和（脯氨酸-脯氨酸-甘氨酸）10的羟化作用。该酶中不对称活性位点的证据。
Biochemistry. 1977 Apr 19;16(8):1615-21. doi: 10.1021/bi00627a014.
6
Characterization of a low-relative-molecular-mass prolyl 4-hydroxylase from the green alga Chlamydomonas reinhardii.莱茵衣藻低相对分子质量脯氨酰4-羟化酶的特性分析
Biochem J. 1987 Jan 15;241(2):483-90. doi: 10.1042/bj2410483.
7
The kinetics of the hydroxylation of procollagen by prolyl 4-hydroxylase. Proposal for a processive mechanism of binding of the dimeric hydroxylating enzyme in relation to the high kcat/Km ratio and a conformational requirement for hydroxylation of -X-Pro-Gly- sequences.脯氨酰4-羟化酶催化前胶原羟基化的动力学。关于二聚体羟化酶结合的连续机制的提议，该机制与高催化常数/米氏常数比值以及对-X-Pro-Gly-序列羟基化的构象要求有关。
Biochim Biophys Acta. 1991 Aug 9;1079(1):103-11. doi: 10.1016/0167-4838(91)90030-4.
8
The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion.脯氨酰4-羟化酶的2-氧代戊二酸结合位点。不同亚位点的鉴定以及在酶结合的亚铁离子处配体反应中2-氧代戊二酸脱羧的证据。
Eur J Biochem. 1984 Jan 16;138(2):239-45. doi: 10.1111/j.1432-1033.1984.tb07907.x.
9
A new prolyl hydroxylase acting on poly-L-proline, from suspension cultured cells of Vinca rosea.一种来自长春花悬浮培养细胞的、作用于聚-L-脯氨酸的新型脯氨酰羟化酶。
Biochim Biophys Acta. 1980 Dec 4;616(2):188-98. doi: 10.1016/0005-2744(80)90137-0.
10
Processive action of the two peptide binding sites of prolyl 4-hydroxylase in the hydroxylation of procollagen.
Biochemistry. 1988 Jan 12;27(1):150-5. doi: 10.1021/bi00401a023.

引用本文的文献

1
Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes.解析5-甲基胞嘧啶氧化TET酶中的2-氧代戊二酸周转和底物氧化动力学。
Commun Chem. 2024 Dec 20;7(1):305. doi: 10.1038/s42004-024-01382-1.
2
Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center.人胶原蛋白脯氨酰4-羟化酶被其铁中心的配体激活。
Biochemistry. 2016 Jun 14;55(23):3224-33. doi: 10.1021/acs.biochem.6b00251. Epub 2016 May 31.
3
Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2).
反溶剂同位素效应表明缺氧诱导因子脯氨酰羟化酶（PHD2）中 aquo 的释放缓慢。
Biochemistry. 2012 Aug 21;51(33):6654-66. doi: 10.1021/bi300229y. Epub 2012 Aug 9.
4
Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species.在人类低氧诱导因子 asparaginyl 羟化酶（FIH）中，O2 的解偶联激活不会产生活性氧。
J Inorg Biochem. 2011 May;105(5):630-6. doi: 10.1016/j.jinorgbio.2011.01.007. Epub 2011 Jan 21.
5
Prolyl 4-hydroxylase.脯氨酰4-羟化酶
Crit Rev Biochem Mol Biol. 2010 Apr;45(2):106-24. doi: 10.3109/10409231003627991.
6
The diverse and pervasive chemistries of the alpha-keto acid dependent enzymes.α-酮酸依赖性酶的多样且普遍存在的化学性质。
J Biol Inorg Chem. 2007 Jun;12(5):587-601. doi: 10.1007/s00775-007-0231-0. Epub 2007 Apr 13.
7
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.构巢曲霉中依赖FeII和α-酮戊二酸的黄嘌呤羟化酶的纯化与特性分析
Biochemistry. 2007 May 8;46(18):5293-304. doi: 10.1021/bi700065h. Epub 2007 Apr 13.
8
Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase.人脯氨酰4-羟化酶的铁和2-氧代戊二酸结合位点的表征
EMBO J. 1997 Mar 17;16(6):1173-80. doi: 10.1093/emboj/16.6.1173.
9
Structural requirements for the utilization of ascorbate analogues in the prolyl 4-hydroxylase reaction.脯氨酰4-羟化酶反应中抗坏血酸类似物利用的结构要求。
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):75-9. doi: 10.1042/bj3000075.
10
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism.香豆酸对鸡胚脯氨酰4-羟化酶的时间依赖性失活。协同催化机制的证据。
Biochem J. 1987 Feb 15;242(1):163-9. doi: 10.1042/bj2420163.