Pezzella F, Mason D Y
Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
Nouv Rev Fr Hematol (1978). 1990;32(6):397-9.
The 14;18 translocation is generally considered a good marker for follicular lymphomas and it has also been suggested that it is of prognostic significance in this disease. It has also been claimed that the bcl-2 protein can be detected by immunohistology only in lymphoma carrying t(14;18). We have raised antibodies to the bcl-2 protein and shown that expression of the protein is not specific for the translocation and have also demonstrated that there is no correlation between prognosis and the presence of the translocation. It is also evident that t(14;18) is present only in about two-thirds of follicular lymphoma patients (and is found in 20-30% of diffuse lymphomas).
14;18易位通常被认为是滤泡性淋巴瘤的一个良好标志物，也有人提出它在这种疾病中具有预后意义。还有人声称，只有在携带t(14;18)的淋巴瘤中才能通过免疫组织化学检测到bcl-2蛋白。我们制备了针对bcl-2蛋白的抗体，并表明该蛋白的表达并非该易位所特有的，还证明了预后与易位的存在之间没有相关性。同样明显的是，t(14;18)仅存在于约三分之二的滤泡性淋巴瘤患者中（在20%-30%的弥漫性淋巴瘤中也可发现）。
