Larsen C J, Mecucci C, Leroux D
Unité 301-INSERM, Institut de Génétique Moléculaire, Paris, France.
Nouv Rev Fr Hematol (1978). 1990;32(6):401-3.
Most human follicular lymphomas bear the specific t(14;18) translocation that juxtaposes the 3' region of bcl-2 to the IgH gene on chromosome 14q+. In some rare cases, t(2;18) and t(18;22) translocations have been observed that involve bcl-2 and either Ig kappa or lambda genes. Strikingly, in these cases all the breakpoints on chromosome 18 are located in the 5' end the bcl-2 gene. These rearrangements are very similar to those recently found in a significant proportion of CLL. Thus, bcl-2 rearrangements in malignant lymphomas cluster in at least three regions: the so-called major breakpoint region (mbr) and minor cluster region (mcr) in more than 85% of t(14;18) translocation, and the newly characterized region 5' of the gene. We propose to call this new cluster region vcr (for variant cluster region).
大多数人类滤泡性淋巴瘤具有特异性的t(14;18)易位，该易位使bcl-2基因的3'区域与14号染色体长臂上的IgH基因并列。在一些罕见病例中，已观察到涉及bcl-2基因以及Igκ或Igλ基因的t(2;18)和t(18;22)易位。引人注目的是，在这些病例中，18号染色体上的所有断点均位于bcl-2基因的5'端。这些重排与最近在相当一部分慢性淋巴细胞白血病（CLL）中发现的重排非常相似。因此，恶性淋巴瘤中的bcl-2重排至少聚集在三个区域：在超过85%的t(14;18)易位中出现的所谓主要断点区域（mbr）和次要簇区域（mcr），以及该基因新鉴定的5'区域。我们建议将这个新的簇区域称为vcr（变异簇区域）。
