Music E, Flezar M, Suskovic S
Univerzitetni institut za pljucne bolezni in tuberkulozo, Golnik.
Plucne Bolesti. 1990 Jul-Dec;42(3-4):199-202.
During three successive days in 14 patients with bronchial asthma after application of Salbutamol directly from the metered-dose inhaler (MDI) or indirectly by spacer the changes of FEF and FEV1 were measured. For inhalation through spacer the double blind crossover trial with placebo was used. Out of 12 patients three of them responded with better flows (FEV1, FEF) after inhalation via MDI. In 7 of them there were no significant differences between ways of application while in two of them the flows by spacer were significantly better. Tachypnea, low lung volumes as well as poor co-operation of the patient, especially elderly, should speak in favour of the use of spacer. However, in young, co-operative asthmatic patients the MDI is suitable. Further controlled studies of new applications of inhalation therapy should be studied.
在14例支气管哮喘患者中，连续三天分别通过定量气雾剂（MDI）直接给药或通过储雾罐间接给药沙丁胺醇后，测量了用力呼气流量（FEF）和第一秒用力呼气容积（FEV1）的变化。对于通过储雾罐吸入，采用了与安慰剂的双盲交叉试验。12例患者中，3例通过MDI吸入后气流（FEV1、FEF）改善。其中7例患者两种给药方式之间无显著差异，而另外2例患者通过储雾罐给药时气流明显更好。呼吸急促、肺容积低以及患者（尤其是老年患者）配合不佳，这些情况支持使用储雾罐。然而，对于年轻、配合良好的哮喘患者，MDI是合适的。应进一步开展吸入疗法新应用的对照研究。
