Higuchi K, Kanazawa T, Ohkawara M, Yuki T, Kobayashi H, Tamura M
Third Department of Internal Medicine, School of Medicine Iwate Medical University, Morioka, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Nov;28(11):1415-20.
Metered dose inhaler (MDI) is widely used in treatment of bronchial asthma. But adequate efficacy is not obtained if the patients use an improper technique of inhalation. The spacer device was designed to reduce such inhalation errors. Three types of spacers (pear type, tube type, paper spacer) were studied to confirm their usefulness in bronchial asthma. Bronchodilating effect of procaterol (10 micrograms/puff X 2) in conventional MDI or MDI with a spacer was evaluated. There were no significant difference in the effect on the pulmonary function after single inhalation of MDI with or without a spacer for 60 minutes. In regular use of MDI with a spacer for two weeks, PEFR and FEV1.0 were slightly improved. These results suggest that effect of MDI with a spacer may be more effective than MDI alone in regular use.
定量吸入器（MDI）广泛应用于支气管哮喘的治疗。但如果患者使用不当的吸入技术，则无法获得足够的疗效。间隔装置旨在减少此类吸入错误。研究了三种类型的间隔器（梨形、管形、纸质间隔器）以确认它们在支气管哮喘中的效用。评估了丙卡特罗（10微克/喷×2）在传统MDI或带间隔器的MDI中的支气管扩张作用。单次吸入带或不带间隔器的MDI 60分钟后，对肺功能的影响没有显著差异。在常规使用带间隔器的MDI两周后，呼气峰流速（PEFR）和第1秒用力呼气容积（FEV1.0）略有改善。这些结果表明，在常规使用中，带间隔器的MDI可能比单独使用MDI更有效。
